Society for Hematopathology

Interactive Education Modules

This series of interactive education modules was created by members of the Society for Hematopathology Education Committee. The modules are intended for pathology residents, hematopathology fellows, and hematology-oncology fellows during their hematopathology rotation in addition to senior residents and fellows wishing to review the material. The modules are self-paced and include interactive elements, quizzes, links to further resources, and short videos.

Disclaimer:
This content is for educational purposes only. It is not intended to be a substitute for professional medical advice. Views expressed by individual presenters do not necessarily reflect the opinion of the Society for Hematopathology.

Please note that you must first log into your member account to access these interactive modules. SH has made the modules “Cytogenetic and Molecular testing in Hematopathology” and “Application of Flow Cytometry in Diagnosis & MRD Testing of Hematologic Neoplasms: Principles” available to the public. In addition, newly posted modules will be available to the public for 2 months, after which a member account will be needed for access.


	Dr. Emily Mason, Dr. Madhu Ouseph, Dr. Yi-Shan Lee, Dr. Jaryse Harris, Dr. Xueyan Chen This module includes four lessons providing an overview of the principles and applications of commonly used cytogenetic and molecular techniques in hematopathology practice.

	Dr. Xueyan Chen, Dr. Emily Mason, Dr. Madhu Ouseph, Dr. Jaryse Harris, Dr. Yi-Shan Lee The first lesson of this flow cytometry module introduces the fundamental principles and technical aspects of clinical flow cytometry. Learners will also review essential concepts in data acquisition, analysis, and interpretation.

	MORPHOLOGIC EVALUATION OF A PERIPHERAL BLOOD SMEAR Dr. Elizabeth Courville, Dr. Laura Brown, Dr. Rose Beck, Dr. Laura Wake, Dr. Julianne Qualtieri, and Dr. Sonam Prakash. This interactive education module provides an introduction to peripheral blood smear morphologic evaluation, including the evaluation of red blood cells, white blood cells, and platelets. Case studies are presented in the separate module "Peripheral Blood Smear Morphologic Evaluation: Case Studies".

	PERIPHERAL BLOOD SMEAR MORPHOLOGIC EVALUATION: CASE STUDIES Dr. Elizabeth Courville, Dr. Laura Brown, Dr. Rose Beck, Dr. Laura Wake, Dr. Julianne Qualtieri, and Dr. Sonam Prakash. This interactive education module uses case studies to provide a review of concepts introduced in the separate module "Morphologic Evaluation of a Peripheral Blood Smear" as well as introduce new topics/entities.

	CHRONIC MYELOID LEUKEMIA IN PEDIATRIC PATIENTS: A CASE STUDY Authors: Dr. Margaret Moore and Dr. Elizabeth Courville Reviewers: Dr. Jayalakshmi Balakrishna and Dr. Alexa Siddon In this module, learners will use a case-based format to review the core clinicopathologic features of chronic myeloid leukemia (CML), with a focus on CML that presents in pediatric and young adult patients. The module highlights testing methodologies used in the diagnostic workup for CML then gives a basic overview of treatment strategies and disease monitoring.

	INTRODUCTION TO BONE MARROW MORPHOLOGY AND EVALUATION Authors: Dr. Laura Brown, Dr. Nadine Aguilera, Dr. Julianne Qualtieri, Dr. Alexa Siddon, Dr. Margaret Moore, Dr. Laura Wake, Dr. Jayalakshmi Balakrishna, Dr. Elizabeth Courville In this module, the learner will be introduced to the basics of bone marrow collection and processing and the general approach to bone marrow examination. The learner will become familiar with the normal bone marrow components and the typical stains performed on aspirate smears and core/clot sections. A description of the ancillary studies used in bone marrow examination will be given, and key features of the bone marrow biopsy report will be discussed.

	FOLLICULAR LYMPHOMA Authors: Dr. Jayalakshmi Balakrishna, Dr. Elizabeth Courville, Dr. Laura Brown, Dr. Julianne Qualtieri, Dr. Alexa Siddon, Dr. Laura Wake This interactive module will present an introduction to follicular lymphoma. Histologic and immunophenotypic features will be discussed and contrasted to reactive follicular hyperplasia. The learner will be introduced to the grading of follicular lymphoma, follicular lymphoma variants, and follicular lymphoma transformation.

	APPROACH TO YOUNG BLOOD: PERIPHERAL BLOOD AND BONE MARROW CASE STUDIES IN PEDIATRIC PATIENTS This module uses a case-based format to review peripheral blood and bone marrow morphology in pediatric patients. Learners review normal morphology at different stages of development and explore non-neoplastic disease processes that commonly present in childhood. Special emphasis is placed on acquired and inherited bone marrow failure syndromes.

	PRACTICAL CASE IN HEMOGLOBIN ELECTROPHORESIS ANALYSIS Dr. Elizabeth Courville, Dr. Alexa Siddon, Dr. Jayalakshmi Balakrishna, Dr. Nadine Aguilera, Dr. Mary Ann Arildsen, Dr. Margaret Moore Using a case-based format, this module explores hemoglobin electrophoresis interpretation by a capillary electrophoresis method. Participants will be introduced to both normal and abnormal capillary electrophoresis patterns and will have the opportunity to practice their approach to hemoglobin electrophoresis interpretation.

	HODGKIN LYMPHOMA Dr. Mary Ann Thompson, Dr. Elizabeth Courville, Dr. Margaret Moore This module is an introduction to the basic clinical and morphologic features of Classic Hodgkin Lymphoma and Nodular Lymphocyte Predominant Hodgkin/B-Cell Lymphoma. Learners will explore key histologic and immunohistochemical features that help establish the diagnoses. In addition, they will learn features that help distinguish Hodgkin lymphomas from other lymphomas with large cell morphology.

	MATURE T-/NK-CELL NEOPLASMS: CLASSIFICATION, DIAGNOSIS, AND CHALLENGES. 2022 UPDATE. Dr. Xueyan Chen, Dr. Elizabeth Courville, Dr. Margaret Moore, Dr. Sam Sadigh This interactive module aims to provide participants with a foundational understanding of the current classification systems for mature T-/NK-cell neoplasms, offering a concise overview of this challenging topic. Exploring a range of diagnostic approaches, the content emphasizes the pivotal role of morphological evaluation, immunophenotyping, molecular studies, and other essential diagnostic modalities. Through a series of interactive case studies, participants will learn to identify and describe the diagnostic features of common mature T-/NK-cell neoplasms, develop the ability to differentiate between various subtypes, and recognize the diagnostic challenges.

	CASE PRESENTATION: 5 WEEK OLD WITH ABDOMINAL DISTENSION AND HEMATOCHEZIA Dr. Mary Ann Thompson, Dr. Robert P Seifert Short case presentation highlighting a hematopoietic malignancy.

	CONGENITAL DYSERYTHROPOIETIC ANEMIA Dr. Elliott Denney, Dr. Christine Smith, Dr. Emily Mason Module creation by Dr. Sam Sadigh.

Interactive Education Modules

EDUCATION